I didn't personally see enough of the films or DVDs/Blu-rays released last year to competently comment on the best of the year. I'll leave that to the professionals:
Adam Jahnke's "The Best Discs of 2010"
Adam Jahnke's Best and Worst Films of 2010
DVD Savant Picks the Most Impressive Discs of 2010
2010: The Year They Finally Got Blu-ray Right
And a bonus: DVD Savant's 2011 DVD Wish List
After a couple of years with few real gems, it's heartening to see so many great discs released in the year that streaming video was labeled "the death of the disc".
To any "Best of 2010" DVD list I would add Vampire Circus and The Green Slime (Stuart Galbraith IV's review), but that's just me.